New data from CCN demonstrate potential of CT to transform the cardiac care pathway

Study presented at ECR 2015 shows how the new Revolution CT scanner can deliver superb image quality with lower dose for cardiac patients, including those with high or irregular heart rates

Opens door for wider use of non-invasive imaging in diagnosis of coronary artery disease

VIENNA, March 4, 2015 - Centre Cardiologique du Nord, Saint Denis today presented data at the European Congress of Radiology (ECR) that show GE Healthcare’s new Revolution* CT scanner could impact the way in which coronary artery disease is diagnosed and managed.   The findings of the study, which was carried out under the leadership of Drs. Jean-Louis Sablayrolles, Laurent Macron and Jacques Feignoux, showed GE Healthcare’s Revolution CT produced  high quality images using lower doses of radiation for cardiac exams even with clinically-challenging patients, contributing to more confident diagnoses at lower patient doses.  According to the authors, the findings suggest the possibility that high performance CTs such as Revolution CT could be used as a first-line examination in the evaluation of coronary artery disease.

Coronary Computed Tomography Angiography (CCTA) is a well-established non-invasive imaging technique used in the detection of coronary artery disease (CAD).  It offers an alternative to exercise stress tests or coronary angiography (IC) for diagnosis, the latter being an invasive procedure that uses a catheter threaded through the blood vessels to the heart.  However, a number of factors limit the use of CCTA in cardiac care.   Patients with high heart rates or arrhythmia can be challenging to diagnose with confidence because high heart rates can introduce motion artefacts, making it difficult to find an appropriate phase of the cardiac cycle suitable for the analysis of all coronary segments.   Levels of radiation exposure for patients are also a concern.   GE Healthcare’s Revolution CT has been developed to help address these challenges, allowing the heart to be imaged in one beat, whatever the heart rate, while helping to reduce dose by up to 82% when the new reconstruction algorithm ASiR-V* is applied1.

The study at CCN scanned 58 patients with high heart rates (>65 bpm) to compare the image quality and radiation dose of the Revolution CT 512-slice scanner with the previous generation 128-slice technology (Discovery CT750 HD).   58 patients with high heart rates were scanned in two groups of 29.  The study found that Revolution CT images ranked higher on a five-point Likert scale.  The Revolution CT also successfully imaged a very high percentage of assessable coronary segments, even though this group of challenging patients had a mean heart rate 75.7 ± 9.9 bpm.

Dr. Sablayrolles, head of CT Cardiac Imaging Radiology at Centre Cardiologique de Nord (CCN) in Saint-Denis, France was the first user of Revolution CT in Europe.  He commented, “These data are in line with our positive experiences using Revolution CT.  It’s able to deliver excellent visualisation of the coronary arteries, which is important for increasing the success rate of cardiac CT exams in our hospital.  The remarkable improvement in image quality gives us much greater confidence when diagnosing even clinically-challenging patients and the lower dose per cardiac exam is a huge advantage.”  He continued, “Many patients with suspected coronary artery disease undergo invasive imaging examinations.  However, non-invasive imaging offers greater comfort to patients.  Performed on an outpatient basis, it also shortens hospital stays.  Revolution CT offers so many advantages and possibilities that high performance CT could help develop of new patient pathway and be used as a first-line examination in the evaluation of coronary artery disease.”

Valerie Brissart, Marketing Director Molecular Imaging and CT at GE said, “GE Healthcare developed the Revolution CT to help radiologists overcome many of their day-to-day challenges and to help them deliver high quality care to their patients.  The Revolution CT offers many advantages to patients and their clinicians.  These include superb image quality, lower dose with ASiR-V, a more comfortable experience for patients, more patient-centred examinations, and the ability to combine anatomical and functional imaging.”  She added, “Revolution CT has the potential to influence the cardiac care pathway.  The combination of lower dose with robust and accurate imaging, even for clinically challenging exams, offers great possibilities for CT to become a more widely-used non-invasive diagnostic tool in cardiac care.”

CCN was the first hospital in Europe to begin using the new GE Healthcare Revolution CT.  Since the system was installed in August 2014, the hospital has scanned more than 1000 cardiac patients and more than 4000 patients in total.

At ECR, a further presentation on the experience of using the Revolution CT for cardiovascular imaging will be made by Prof. Schmitt, Herz-und Gefäß-Klinik GmbH, Germany at the GE Healthcare symposium on Saturday 7th March at 12.30.

1. In clinical practice, the use of ASiR‐V may reduce CT patient dose depending on the clinical task, patient size, anatomical location, and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. Low Contrast Detectability (LCD), Image Noise, Spatial Resolution and Artifact were assessed using reference factory protocols comparing ASiR‐V and FBP. The LCD measured in 0.625 mm slices and tested for both head and body modes using the MITA CT IQ Phantom (CCT183, The Phantom Laboratory), using model observer method.

*Trademark of General Electric Company

About CCN

Centre Cardiologique du Nord, Saint-Denis (France) is a private clinic of over 220 beds created by a cardiology group that is dedicated to the treatment of cardiovascular pathologies. CCN performs over 1000 cardiac interventions each year and is considered as one of the finest cardiovascular centers in the world.

About GE Healthcare

GE Healthcare provides transformational medical technologies and services to meet the demand for increased access, enhanced quality and more affordable healthcare around the world. GE (NYSE: GE) works on things that matter - great people and technologies taking on tough challenges. From medical imaging, software & IT, patient monitoring and diagnostics to drug discovery, biopharmaceutical manufacturing technologies and performance improvement solutions, GE Healthcare helps medical professionals deliver great healthcare to their patients.  For more information visit our website www.gehealthcare.com

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